I've been meaning to post on this paper for a long time. It's old but not ancient (2006). The authors are interesting. Collier CA i...
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Acetoacetate and arterial oxygen tension
This is very exciting. Remi forwarded it to me. He understands. Therapeutic ketosis with ketone ester delays central nervous system oxygen ...
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Protons (42) Metformin as the next epilepsy drug?
Some things which are written in stone are not quite as they seem. In a chat to karl about metformin/lactate in the brain I started thinking...
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Protons (41) Metformin in the liver
Just a brief note on metformin. No need for detailed analysis as there's not much to argue with. I think they are correct, even if we ha...
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Protons (40) Living without the glycerophosphate shuttle
If we look at a mouse with a deletion of the gene for cytoplasmicG3Pdh we have a reasonable model for elimination of the glycerophosphate s...
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Protons (39) mtG3Pdh and lactate vs pyruvate
Here is a schematic illustration of the generation of lactate from glucose as suggested by Schurr , ready for doodling on: In more artistic ...
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Protons (37) full glycerophosphate shuttle knockout mice
Just a short post on this paper: Lethal Hypoglycemic Ketosis and Glyceroluria in Mice Lacking Both the Mitochondrial and the Cytosolic Glyce...
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Protons (38) and ultra low fat once more
OMG, here we go with more doodles. Ah well... This post is a summary of the ideas which came out of the Protons thread. I’ve been meaning to...
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Meet the researchers with the PKCζ deletion
Let's get this straight, right at the start: If you have cancer your outlook is probably worse if that cancer cell population has lost i...
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Protons (36) Glycolysis to lactate
Before we can even begin to think about metformin and mtG3Pdh we have to re examine lactate and glycolysis. It's difficult to over empha...
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Confirmation bias is not just in my head
I've been sent a link to this study: Body fat loss and compensatory mechanisms in response to different doses of aerobic exercise—a rand...
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Confirmation Bias in my head
Sometimes you get a reminder that you suffer from Confirmation Bias. I do. This morning I went back and dug out the study from Aberdeen: Die...
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